热敏电阻器
材料科学
微型加热器
流量测量
流速
生物医学工程
脉动流
血流
流量(数学)
校准
声学
制作
机械
电气工程
医学
放射科
数学
统计
替代医学
心脏病学
病理
工程类
物理
作者
Myoung-Ock Cho,Sun Young Kim,Seunghyun Back,Woo-Jin Jang,Jin Ho Choi,Bongchul Kang,Si‐Hyung Lim
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2023-12-07
卷期号:9 (2): 602-614
标识
DOI:10.1021/acssensors.3c01262
摘要
In this study, an ultraslim thermal flow sensor system integrated onto a 340 μm diameter medical guidewire was developed using a laser filament scanning sintering method for the early diagnosis of cardiovascular diseases. The proposed system is a calorimetric-based micro thermal flow sensor comprising a microheater and two thermistors. Prior to fabrication, the sensor design was optimized through flow simulation, and the patterned sensor was successfully implemented on a thin and curved surface of the medical guidewire using a laser patterning method with Ag nanoparticles. The performance of the ultraslim thermal flow sensor-on-guidewire system (SoW) was evaluated under pulsatile flow by using an artificial heartbeat simulator with differentially induced fluid flow velocities of up to 60 cm/s. The resulting electrical signals generated by the temperature difference between the two thermistors caused by the fluid flow were measured across different velocity ranges. Based on the obtained data, a calibration curve was derived to establish the relationship between the fluid velocity and the sensor output voltage. Furthermore, the SoW was tested on living animals, whereby the measured blood flow velocities were 60-90 cm/s in the left coronary artery of pigs. This research demonstrates the potential of ultraslim microsensors, such as the developed thermal flow sensor system, for various industries, particularly in the medical field.
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