工艺工程
批处理
计算机科学
过程开发
组合化学
化学
工程类
程序设计语言
作者
Lei Song,Hwee Ting Ang,Jagadeesan Senthilperumal,Umamaheswara Rao Kanusu,Sivasankaran Venugopal,Naveen Rangarajan,Sankarganesh Krishnamoorthy,Srinivas Reddy Dubbaka,Patrick O’Neill,Jie Wu
标识
DOI:10.1021/acs.oprd.4c00020
摘要
In this paper, we present the development of a safe water-based synthesis of 1,2,3-triazole using cheap raw materials. Starting from glyoxal and hydrazine, a safe and efficient three-step end-to-end continuous process was developed. This protocol transforms heterogeneous batch reactions into a homogeneous streamlined continuous flow system. This advancement not only obviated the separation of hazardous intermediates, thereby mitigating potential risks, but also significantly diminished the reaction time of each step. This has ensured a rapid and stable supply of 1,2,3-triazole for downstream product development such as tazobactam. Additionally, the study delves into the insights gained from transitioning from batch reactions to continuous flow processes, highlighting the practical and safety benefits of continuous flow synthesis.
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