肉芽组织
伤口愈合
血管生成
医学
移植
线粒体
外科
癌症研究
细胞生物学
生物
作者
Ömer Faruk Taner,Oner Ulger,Simay Ersahin,Nesrin Tan Başer,Onur Genç,Gökhan Burçin Kubat
标识
DOI:10.1016/j.jcyt.2024.02.027
摘要
Wound healing is a multistage process that requires a concerted effort of various cell types. The intricate processes involved in the healing of wounds result in high energy requirements. Furthermore, mitochondria play a crucial role in the healing process because of their involvement in neo angiogenesis, growth factor synthesis, and cell differentiation. It is unclear how mitochondria transplantation, a promising new approach, influences wound healing.In this study, healthy autologous mitochondria obtained from skeletal muscle were injected into chronic pressure wounds as an intervention to promote wound healing.Mitochondrial transplantation accelerated wound healing by reducing wound size, increasing granulation tissue, and hastening epithelialization.This study is the first to demonstrate the therapeutic efficacy of mitochondrial transplantation in wound healing.
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