嵌合抗原受体
细胞疗法
CD8型
抗原
免疫疗法
受体
免疫学
细胞毒性T细胞
T细胞受体
生物
T细胞
癌症研究
细胞
医学
免疫系统
遗传学
体外
作者
Chao Sun,Dan Li,Zhengxin Wang
出处
期刊:Immunotherapy
[Future Medicine]
日期:2024-01-24
标识
DOI:10.2217/imt-2023-0170
摘要
Chimeric antigen receptor (CAR) T-cell therapy for malignant tumors has reached a crucial stage, with recent studies underscoring the role of T-cell exhaustion in determining the efficacy of CAR-T therapy. This trailblazing discovery has opened new avenues to augment the potency of CAR-T therapy. Basic leucine zipper ATF-like transcription factor ( BATF) is indispensable in alleviating T-cell exhaustion and is pivotal in the early stages of CD8 + T-cell differentiation. In cooperation with other transcription factors, it plays a key role in the differentiation and maturation processes of exhausted T cells. A deeper comprehension of BATF‘s mechanisms in T-cell biology may yield novel insights into amplifying the efficacy of CAR-T therapy.
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