免疫系统
肿瘤微环境
抗原
获得性免疫系统
促炎细胞因子
癌症研究
免疫学
免疫
T细胞
生物
医学
炎症
作者
Yajie Sun,Yu Tian,Shuhui Wu,Ai Huang,Yan Hu,Zhiyun Liao,Michelle Swift,Suke Deng,Yang Xiao,Bin Zhang,Zhanjie Zhang,Bian Wu,Jing Huang,Ke Jiang,Fen Huang,Jin Huang,Chao Wan,Kunyu Yang
标识
DOI:10.1016/j.xcrm.2023.101303
摘要
The inadequate activation of antigen-presenting cells, the entanglement of T cells, and the highly immunosuppressive conditions in the tumor microenvironment (TME) are important factors that limit the effectiveness of cancer vaccines. Studies show that a personalized and broad antigen repertoire fully activates anti-tumor immunity and that inhibiting the function of transforming growth factor (TGF)-β facilitates T cell migration. In our study, we introduce a vaccine strategy by engineering irradiated tumor cell-derived microparticles (RT-MPs), which have both personalized and broad antigen repertoire, to induce comprehensive anti-tumor effects. Encouraged by the proinflammatory effects of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the high affinity between TGF-β receptor 2 (TGFBR2) and TGF-β, we develop RT-MPs with the SARS-CoV-2 spike protein and TGFBR2. This spike protein and high TGFBR2 expression induce the innate immune response and ameliorate the immunosuppressive TME, thereby promoting T cell activation and infiltration and ultimately inhibiting tumor growth. Our study provides a strategy for producing an effective personalized anti-tumor vaccine.
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