血管平滑肌
炎症
烟酰胺腺嘌呤二核苷酸磷酸
卡尔波宁
高同型半胱氨酸血症
活性氧
同型半胱氨酸
弹性蛋白
药理学
生物化学
生物
化学
内分泌学
内科学
医学
免疫学
氧化酶试验
病理
酶
平滑肌
肌动蛋白
作者
Ae Sin Lee,Yiseul Kim,Haeng Jeon Hur,Sang‐Hee Lee,Mi Jeong Sung
出处
期刊:Journal of Medicinal Food
[Mary Ann Liebert]
日期:2023-12-01
卷期号:26 (12): 869-876
标识
DOI:10.1089/jmf.2023.k.0058
摘要
Hyperhomocysteinemia is a main risk factor for phenotypic modulation of vascular smooth muscle cells (VSMCs) and atherosclerosis. Phenotypic switching and proliferation of VSMCs are related to the progression of vascular inflammation. Chrysanthemum coronarium L. is a leafy vegetable with various biological functions, such as antioxidative, anti-inflammatory, and antiproliferative effects. In this study, we aimed to identify the mechanisms underlying the therapeutic and preventive effects of C. coronarium L. extract (CC) in regulating homocysteine (Hcy)-induced vascular inflammation in human aortic VSMCs. CC did not exhibit cytotoxicity and inhibited Hcy-stimulated VSMC proliferation and migration. In addition, CC promoted Hcy-induced expression of VSMC contractile phenotype proteins, including alpha-smooth muscle actin, calponin, and smooth muscle 22α. CC also decreased Hcy-induced accumulation of reactive oxygen species and expression of inflammatory markers nicotinamide adenine dinucleotide phosphate oxidase-4 and soluble epoxide hydrolase. These results showed that CC attenuates Hcy-induced inflammatory responses, highlighting its potential as a therapeutic or preventive target for Hcy-induced vascular inflammation.
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