粒体自噬
内分泌学
缺氧（环境）
内科学
内皮功能障碍
生物
发病机制
内皮干细胞
肺动脉高压
糖酵解
内皮
医学
化学
新陈代谢
生物化学
体外
自噬
细胞凋亡
氧气
有机化学
作者
Yandong Pei,Dongfeng Ren,Yibing Yin,Jiajia Shi,Qianyuan Ai,Wenxin Hao,Xiaofan Luo,Chenyue Zhang,Yanping Zhao,Cai-Yun Bai,Lin Zhu,Qiong Wang,S. Y. Li,Yuwei Zhang,Jiangtao Lu,Lin Liu,Lin Zhou,Yuli Wu,Yiqi Weng,Yongle Jing
标识
DOI：10.1161/circresaha.124.325156
摘要
Collectively, we show that FUNDC1-mediated basal mitophagy is critical for endothelial homeostasis, and its disruption instigates PH pathogenesis. Given that similar changes in FUNDC1 and IGFBP2 were observed in PH patients, our findings are of significant clinical relevance and provide novel therapeutic strategies for PH.
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(2025-6-4)
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