化学
烷基
喹啉
芳基
催化作用
亲核细胞
联轴节(管道)
药物化学
光催化
偶联反应
有机化学
光化学
光催化
机械工程
工程类
作者
Anthony N. Cauley,Antonio Ramı́rez,Chandan L. Barhate,Andrew F. Donnell,Purnima Khandelwal,Melda Sezen-Edmonds,Trevor C. Sherwood,Jack L. Sloane,Cullen L. Cavallaro,Eric M. Simmons
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-08-03
卷期号:24 (31): 5663-5668
被引量:3
标识
DOI:10.1021/acs.orglett.2c01942
摘要
Utilizing quinoline as a mild, catalytic additive, broadly applicable conditions for the Ni/photoredox-catalyzed C(sp2)–C(sp3) cross-coupling of (hetero)aryl bromides and alkyl pinacolboronate esters were developed, which can be applied to both batch and flow reactions. In addition to primary benzylic nucleophiles, both stabilized and nonstabilized secondary alkyl boronic esters are effective coupling partners. Density functional theory calculations suggest that alkyl radical generation occurs from an alkyl-B(pin)-quinoline complex, which may proceed via an energy transfer process.
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