摩擦电效应
纳米发生器
刺激
聚二甲基硅氧烷
成纤维细胞
材料科学
生物医学工程
细胞迁移
刮擦
伤口愈合
细胞生长
纳米技术
医学
细胞
化学
细胞培养
外科
内科学
生物
复合材料
压电
生物化学
遗传学
作者
Razieh Nazari-Vanani,Mohaddeseh Vafaiee,Elham Asadian,Raheleh Mohammadpour,Hashem Rafii-Tabar,Pezhman Sasanpour
出处
期刊:Biomaterials advances
日期:2023-06-01
卷期号:149: 213364-213364
被引量:6
标识
DOI:10.1016/j.bioadv.2023.213364
摘要
Skin wounds are common in accidental injuries, surgical operations, and chronic diseases. The migration and proliferation of fibroblast cells are fundamental to wound healing, which can be promoted by electrical stimulation as a physical therapy modality. Therefore, the development of portable electrical stimulation devices that can be used by patients on-site is an essential need. In the present study, a self-cleaning triboelectric nanogenerator (TENG) has been fabricated for enhancing cell proliferation and migration. The polycaprolactone‑titanium dioxide (PCL/TiO2) and polydimethylsiloxane (PDMS) layers were fabricated via a facile method and used as the electropositive and electronegative pair, respectively. The effect of stimulation time on proliferation and migration of fibroblast cells was investigated. The results demonstrated that when the cells were stimulated once-a-day for 40 min, the cell viability was increased, while a long daily stimulation time has an inhibitory effect. Under electrical stimulation, the cells move toward the middle of the scratch, making the scratch almost invisible. During repeated movements, the prepared TENG connected to a rat skin generated an open-circuit voltage and a short-circuit current around 4 V and 0.2 μA, respectively. The proposed self-powered device can pave the way for a promising therapeutic strategy for patients with chronic wounds.
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