In advanced progressive CKD, discontinuing RAS inhibitors did not improve eGFR at 3 y

ACP Journal ClubMarch 2023In advanced progressive CKD, discontinuing RAS inhibitors did not improve eGFR at 3 yDonald Molony, MD, Andrew Horvit, BS, Dia Waguespack, MDDonald Molony, MDUniversity of Texas Health Science Center at Houston–McGovern Medical School, Houston, Texas, USA (D.M., A.H., D.W.)Search for more papers by this author, Andrew Horvit, BSUniversity of Texas Health Science Center at Houston–McGovern Medical School, Houston, Texas, USA (D.M., A.H., D.W.)Search for more papers by this author, Dia Waguespack, MDUniversity of Texas Health Science Center at Houston–McGovern Medical School, Houston, Texas, USA (D.M., A.H., D.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/J23-0001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBhandari S, Mehta S, Khwaja A, et al. Renin–angiotensin system inhibition in advanced chronic kidney disease. N Engl J Med. 2022;387:2021-32. https://pubmed.ncbi.nlm.nih.gov/36326117Clinical Impact RatingsGIM/FP/GP: Cardiology: Nephrology: References1. Ahmed A, Kamath N, Kossi M, et al. The impact of stopping inhibitors of the renin–angiotensin system in patients with advanced chronic kidney disease. Nephrol Dial Transplant. 2010;25:3977-82. [PMID: 19820248] Google Scholar2. Zhang Y, He D, Zhang W, et al. ACE inhibitors benefit to kidney and cardiovascular outcomes for patients with non-dialysis chronic kidney disease stages 3-5: a network meta-analysis of randomised clinical trials. Drugs. 2020;80:797-811. [PMID: 32333236] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Health Science Center at Houston–McGovern Medical School, Houston, Texas, USA (D.M., A.H., D.W.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=J23-0001.This article was published at Annals.org on 7 March 2023.ACP Journal Club is editorially independent from Annals of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Current IssueMarch 2023Volume 176, Issue 3Page: JC28KeywordsACE inhibitorsBlood pressureChronic kidney diseaseEstimated glomerular filtration rateKidneysMedical dialysisMyocardial infarctionRenal failureRenal transplantation ePublished: 7 March 2023 Issue Published: March 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...