化学
级联
键裂
催化作用
组合化学
戒指(化学)
劈理(地质)
DHPS公司
表面改性
药物化学
氧化磷酸化
立体化学
有机化学
物理化学
材料科学
生物
复合材料
生物化学
免疫学
疟疾
恶性疟原虫
色谱法
断裂(地质)
作者
Yulin Sun,Zhangmengjie Chai,Donghan Liu,Mingshuai Zhang,Longkun Chen,Zhuoyuan Liu,Yongchao Wang,Fuchao Yu
标识
DOI:10.1002/chem.202300297
摘要
Using benzylamines as the C4 source of 1,4-dihydropyridines (1,4-DHPs), a Cu-catalyzed oxidative [1+2+1+2] cascade cyclization for the synthesis of 1,4-DHPs was firstly developed. A broad range of easily available N,N-dimethyl enaminones and benzylamines are employed smoothly to provide a diverse range of 1,4-DHPs with high efficiency. This method is performed by a one-pot cascade C(sp3)−H bond functionalization/C(sp3)−N cleavage/cyclization strategy to form simultaneously two C(sp3)−C(sp2) bonds, two C(sp2)−N bonds, and a 1,4-DHP ring.
科研通智能强力驱动
Strongly Powered by AbleSci AI