基质金属蛋白酶
平衡
蛋白酵素
金属蛋白酶
生物
细胞外基质
细胞生物学
神经科学
生物信息学
酶
生物化学
作者
Maike Kümper,Joy Steinkamp,Paola Zigrino
出处
期刊:American Journal of Physiology-cell Physiology
[American Physical Society]
日期:2022-09-12
卷期号:323 (4): C1290-C1303
被引量:12
标识
DOI:10.1152/ajpcell.00450.2021
摘要
Maintenance of skin homeostasis is a highly regulated and complex process involving a continuous remodeling by several extracellular matrix proteases, including metalloproteinases. The expression and activity of all metalloproteinases are under strict control, and their deregulation is often associated with diseases or chronic conditions, thereby being considered popular targets for developing new therapeutics. This review will highlight metalloproteinases of the MMP and ADAM families with functions in dermal homeostasis and give some insights into the mechanisms regulating their activity and expression. Furthermore, we discuss how the dysregulation of the most prominent family members affects dermal homeostasis by triggering disease development and influencing progression, focusing on cancer and aging. Here, recent discoveries and new approaches that target or exploit metalloproteinase activity in therapy are emphasized. The potential of naturally derived components in regulating metalloproteinase expression and activity in disease is discussed.
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