内化
体内
阳离子脂质体
趋化性
体外
脂质体
细胞生物学
炎症
化学
细胞
生物
免疫学
受体
转染
生物化学
生物技术
基因
作者
Yanan Xue,Yue Wu,Wei Wang,Lingjing Xue,Zhigui Su,Can Zhang
标识
DOI:10.1021/acs.molpharmaceut.9b00342
摘要
Given the multiple interactions between neutrophils (NEs) and atherosclerosis (AS), in this study, we exploited NEs as cellular vehicles loaded with cationic liposomes for actively targeting atherosclerotic sites. The cellular vehicles based on NEs possess efficient internalization of cationic liposomes and sensitive response to the chemotaxis of atherosclerotic inflammatory cells, which ultimately realize the targeted delivery of the cargos into the target cells in vitro. Moreover, these effects also translated to significant enhancement of the accumulation of NEs’ cargos into the atherosclerotic plaque in vivo after administering NE vehicles to the AS animal model. Consequently, cellular vehicles based on NEs could be a novel strategy for targeted delivery of payloads into atherosclerotic plaque, which would facilitate theranostics for AS and the development of anti-AS drugs to manage the disease.
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