疾病
病因学
人口
阿尔茨海默病
民族
流行病学
基因检测
小胶质细胞
医学
神经科学
心理学
老年学
生物
遗传学
精神科
免疫学
病理
环境卫生
政治学
法学
炎症
出处
期刊:Journal of Law Medicine & Ethics
[Cambridge University Press]
日期:2018-01-01
卷期号:46 (3): 694-698
被引量:31
标识
DOI:10.1177/1073110518804230
摘要
Alzheimer disease (AD) is a huge and growing societal problem with upwards of 35% of the population over the age of 80 developing the disease. AD results in a loss of memory, the ability to make reasoned and sound decisions, and ultimately the inability to take care of oneself. AD has an impact not only on the sufferer, but their caretakers and loved ones, who must take on a costly and time-consuming burden of care. AD is found in virtually all racial and ethnic groups. Genetic influences on AD are substantial, and there has been a 30 year history of both success and failure. Mutations for rare early onset forms of the disease have been identified, but this information has not yet led to an effective treatment. Multiple common genetic variations have also been identified, and have led to new insights into the potential role of microglia cells in addition to neuronal cells in the brain. Despite intensive efforts, a significant portion of the genetic etiology of AD remains unknown and must be identified.
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