神经保护
长时程增强
神经科学
硫化氢
一氧化氮
谷氨酸受体
疾病
病态的
医学
胱硫醚β合酶
机制(生物学)
药理学
内科学
作者
Mohit Kumar,Rajat Sandhir
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science]
日期:2018-01-01
卷期号:17 (9): 654-670
被引量:38
标识
DOI:10.2174/1871527317666180605072018
摘要
Background & Objective: Hydrogen sulfide [H2S] has been widely known as a toxic gas for more than 300 years in the scientific community. However, the understanding about this small molecule has changed after the discovery of involvement of H2S in physiological and pathological mechanisms in brain. H2S is a third gasotransmitter and neuromodulator after carbon monoxide [CO] and nitric oxide [NO]. H2S plays an important role in memory and cognition by regulating long-term potentiation [LTP] and calcium homeostasis in neuronal cells. The disturbances in endogenous H2S levels and trans-sulfuration pathway have been implicated in neurodegenerative disorders like Alzheimer’s disease, Parkinson disease, stroke and traumatic brain injury. According to the results obtained from various studies, H2S not only behaves as neuromodulator but also is a potent antioxidant, anti-inflammatory and anti-apoptotic molecule suggesting its neuroprotective potential. Conclusion: Recently, there is an increased interest in developing H2S releasing pharmaceuticals to target various neurological disorders. This review covers the information about the involvement of H2S in neurodegenerative diseases, its molecular targets and its role as potential therapeutic molecule.
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