Inhalation parameters from an integrated electronic multidose dry powder inhaler (eMDPI)

Background: An electronic module has been integrated in a multidose dry powder inhaler (eMDPI). Sensors inside this device capture inhalation parameters (IP) and a timestamp for each inhalation. Aims/Objectives: To determine the accuracy of the eMDPI to measure IPs: peak inspiratory flow (PIF), inhalation volume (Vin) and inhalation time (Ti). Methods: Patients with asthma (CHILD, ADULT) and COPD were instructed to take 3 separate and fast inhalations through an empty eMDPI (Teva Pharmaceuticals). Each eMDPI was connected to an inhalation profile recorder (IPR). Ethical approval was obtained. Results: In total, 441 inhalations were evaluated among 148 patients (147 inhalations per group; 3 inhalations were missing from the CHILD group). Mean (SD) age of CHILD, ADULT, COPD and ALL patients was 9.8 (3.4), 40.8 (10.6), 66.6 (6.8) and 38.9 (24.5) years, respectively. Inhalation details are provided in Table 1. Conclusion: The eMDPI provides accurate measurement of inhalation parameters when used by patients. Funding: Teva Pharmaceutical Industries Table 1. Mean(SD) Inhalation Parameters and eMDPI-IPR Difference