骨整合
二价
表面改性
化学
免疫原性
骨重建
植入
骨组织
生物陶瓷
材料科学
生物医学工程
纳米技术
免疫学
医学
内科学
外科
免疫系统
物理化学
有机化学
作者
Jiaxing Gong,Miao Sun,Shaolong Wang,Jianxiang He,Yu Wang,Ying Qian,Yu Liu,Lingqing Dong,Liang Ma,Kui Cheng,Wenjian Weng,Mengfei Yu,Yu Shrike Zhang,Huiming Wang
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2019-05-23
卷期号:5 (7): 3311-3324
被引量:15
标识
DOI:10.1021/acsbiomaterials.9b00270
摘要
Divalent main-group-elemental ions are widely used to improve osteogenic capacity of implants biofabricated from Ti and its alloys. However, the conclusions regarding their osseointegration and immunogenicity are always inconsistent because of the multiple bone remodeling processes as well as the distinct material surface features arising from processing. Here we successfully manufactured the porous micro/nanostructured surface topography with divalent main-group-elemental ions (Mg2+, Ca2+, Sr2+, Ba2+) on substrates through hydrothermal treatment and comprehensively evaluated the complex bone remodeling processes, including osseointegration, immunogenicity, and fibrosis of substrates and implants. We found that Sr-modified implants not only upregulated the adhesion and proliferation of mesenchymal stem cells but also the differentiation of osteogenic markers compared with those modified by other divalent main-group-elemental ions (Mg2+, Ca2+, Ba2+). More importantly, the osteoclastogenesis, immunogenicity, and fibrosis of Sr-modified implants were also significantly downregulated. In vivo, evaluations of new bone formation and histological morphology at the interface of implant and host as well as the removal torque similarly indicated the improved osseointegration of Sr-modified implants as well as the absence of immunogenicity, fibrosis, or necrosis. Our results suggested that among various divalent main-group-elemental ions, Sr2+ might be a promising one for enhancing bone remodeling, which can be used to instruct functionalization of the surfaces of biofabricated Ti-based orthopedic and dental implants in the future.
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