大戟科
立体化学
二萜
分馏
萜类
化学
圆二色性
生药学
大戟
选择性
绝对构型
生物活性
有机化学
体外
生物
植物
生物化学
催化作用
作者
Ya-Si Huang,Yan Lu,Chin‐Ho Chen,Kuo‐Hsiung Lee,Daofeng Chen
标识
DOI:10.1021/acs.jnatprod.9b00088
摘要
Two new (1 and 2) and 14 known (3-16) ingenane diterpenoids were isolated from the roots of Euphorbia ebracteolata by bioassay-guided fractionation together with UPLC-MS n analysis. The absolute configurations of the new diterpenoids were established from electronic circular dichroism (ECD) data and ECD calculations. Except for ingenol (16), the ingenane diterpenoids with long aliphatic chain substituents (1-15) exhibited potent activities against HIV-1, with IC50 values of 0.7 to 9.7 nM and selectivity index values of 96.2 to 20 263. From the results, it was concluded that long aliphatic chain substituents are required for the enhanced anti-HIV activity of ingenane diterpenoids.
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