肌炎
病理
结缔组织病
抗合成酶综合征
内科学
肺纤维化
特发性肺纤维化
作者
Shogo Matsuda,Takuya Kotani,Takaaki Ishida,Keisuke Fukui,Youhei Fujiki,Takayasu Suzuka,Koji Nagai,Kenichiro Hata,Takeshi Shoda,Kentaro Isoda,Yuri Ito,Shigeki Makino,Tohru Takeuchi,Shigeki Arawaka
出处
期刊:Rheumatology
[Oxford University Press]
日期:2019-07-18
卷期号:59 (2): 310-318
被引量:9
标识
DOI:10.1093/rheumatology/kez301
摘要
Objectives To elucidate the serum cytokine profile and address the pathomechanism of interstitial lung disease (ILD) complicated with PM/DM. Methods Forty patients with PM/DM-ILD were enrolled, and principal components analysis and cluster analysis were performed to classify patients into subgroups. Additionally, we compared cytokine profiles between the survivors and dead patients and between anti-melanoma differentiation-associated gene 5 antibody- and anti-aminoacyl tRNA synthetase antibody-positive ILD patients. We also examined the association of various cytokines with disease activity indicators and prognosis of ILD. Results The principal components analysis data allowed classification of the cytokine profile into three groups: group 1, neutrophilic and M1-macrophage-driven cytokines; group 2, type 1 Th cell-driven and M2-macrophage-induced cytokines; and group 3, M2-macrophage-driven cytokines. Cluster analysis showed the presence of PM/DM-ILD patient groups with high or low levels of total cytokines. Ninety percent of patients who died of ILD were included in clusters with high cytokine levels. Serum cytokine levels of all groups were significantly higher in the anti-melanoma differentiation-associated gene 5 antibody-positive patients than in the anti-aminoacyl tRNA synthetase antibody-positive patients. Groups 1 and 2 significantly correlated with known factors for poor prognosis, such as serum ferritin levels and alveolar-arterial oxygen difference. Serum cytokine levels of patients in group 1 were significantly higher initially and at 2 and 4 weeks in those who died. Conclusion These findings suggested that the activation of monocytes, macrophages and type 1 Th cells, and neutrophils play roles in the pathomechanism of PM/DM-ILD, and group 1 cytokines could be useful biomarkers for predicting prognosis of PM/DM-ILD.
科研通智能强力驱动
Strongly Powered by AbleSci AI