光热治疗
氧化还原
原位
雷公藤甲素
对偶(语法数字)
光热效应
材料科学
生物物理学
纳米技术
化学
化学工程
生物化学
有机化学
冶金
生物
细胞凋亡
艺术
工程类
文学类
作者
Haijun Liu,Mingming Wang,Xinran Hu,Shanshan Shi,Pao Xu
出处
期刊:Small
[Wiley]
日期:2020-08-14
卷期号:16 (38)
被引量:44
标识
DOI:10.1002/smll.202003398
摘要
Abstract Photothermal therapy (PTT) has attracted tremendous attention due to its noninvasiveness and localized treatment advantages. However, heat shock proteins (HSPs) associated self‐preservation mechanisms bestow cancer cells thermoresistance to protect them from the damage of PTT. To minimize the thermoresistance of cancer cells and improve the efficacy of PTT, an integrated on‐demand nanoplatform composed of a photothermal conversion core (gold nanorod, GNR), a cargo of a HSPs inhibitor (triptolide, TPL), a mesoporous silica based nanoreservoir, and a photothermal and redox di‐responsive polymer shell is developed. The nanoplatform can be enriched in the tumor site, and internalized into cancer cells, releasing the encapsulated TPL under the trigger of intracellular elevated glutathione and near‐infrared laser irradiation. Ultimately, the liberated TPL could diminish thermoresistance of cancer cells by antagonizing the PTT induced heat shock response via multiple mechanisms to maximize the PTT effect for cancer treatment.
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