光动力疗法
外体
肿瘤微环境
化学
微泡
光敏剂
渗透(战争)
聚集诱导发射
生物物理学
癌症研究
纳米技术
材料科学
肿瘤细胞
生物化学
荧光
医学
小RNA
生物
有机化学
工程类
物理
基因
量子力学
运筹学
作者
Delan Zhu,Yanhong Duo,Meng Suo,Yonghua Zhao,Ligang Xia,Zheng Zhang,Li Yang,Ben Zhong Tang
标识
DOI:10.1002/ange.202003672
摘要
Abstract The development of novel photosensitizing agents with aggregation‐induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor‐exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor‐exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen‐based PDT systems and underscores the potential clinical value of AIEgens.
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