化学
钯
磷化氢
腈
配体(生物化学)
催化作用
组合化学
结构异构体
替代(逻辑)
药物化学
有机化学
计算机科学
生物化学
受体
程序设计语言
作者
Kento Asai,Koji Hirano,Masahiro Miura
标识
DOI:10.1021/acs.joc.0c01861
摘要
Ligand-controlled palladium-catalyzed divergent synthesis of isonitriles and nitriles from benzylic carbonates and TMSCN has been developed. The BINAP- or DPEphos-ligated palladium catalyst selectively provides the corresponding benzylic isonitriles, whereas their regioisomers, benzylic nitriles, are formed exclusively under phosphine ligand-free conditions. Mechanistic studies reveal that isonitrile is the primary product under both conditions, but it is isomerized into nitrile in the absence of ancillary phosphine ligands.
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