活性氧
姜黄素
急性肾损伤
天然产物
纳米点
横纹肌溶解症
配位聚合物
材料科学
医学
纳米技术
聚合物
化学
生物化学
外科
有机化学
内科学
作者
Rui Zhang,Liang Cheng,Ziliang Dong,Linqian Hou,Shaohua Zhang,Zhouqi Meng,Oshra Betzer,Yihua Wang,Rachela Popovtzer,Zhuang Liu
出处
期刊:Materials horizons
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:8 (4): 1314-1322
被引量:36
摘要
Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.
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