再生(生物学)
表面改性
静电纺丝
组织工程
细胞外基质
材料科学
纳米纤维
生物医学工程
脚手架
纳米技术
化学
聚合物
医学
细胞生物学
复合材料
生物
物理化学
生物化学
作者
Jiaqi Qian,Zhe Lin,Yanyun Liu,Ziyi Wang,Yandai Lin,Chenchi Gong,Renjie Ruan,Jin Zhang,Huanghao Yang
标识
DOI:10.1016/j.smaim.2021.07.006
摘要
Despite the high number of nerve injuries, there is a lack of an effective nerve repair strategy to restore nerve function. As crucial candidates for tissue engineering, electrospun nanofibrous scaffolds mimic native fibrous extracellular matrix and create a suitable micro-environment guiding nerve regeneration. In this review, electrospinning scaffolds fabricated using natural, synthetic, and composite materials have been summarized. Moreover, we have also summarized strategies commonly used to optimize nerve regeneration, including topologies, bioelectricity, surface functionalization with bioactive molecules, and the addition of anti-inflammatory drugs. In addition, this review has discussed the limitations of scaffolds for nerve regeneration and gives an outlook for future research.
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