化学
脱羧
烷基化
立体中心
催化作用
四级碳
对映选择合成
组合化学
立体化学
有机化学
作者
Sheng Cao,Chen Li,Xuan Wang,Yilei Huang,Guang Yang,Yukun Luo,Shuanglin Qin
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2021-09-29
卷期号:32 (20): 2063-2066
摘要
Abstract A robust Pd(0)-catalyzed decarboxylation alkylation has been developed to construct quaternary stereocenters through the use of chiral tert-butanesulfinamide as the directing group. This strategy provides a simple and efficient route to the construction of quaternary chiral centers at the α-position of chiral sulfinamides, with high diastereoselectivities and high yields.
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