Calcium‐Catalyzed Intramolecular Hydroamination‐Deacylation Reaction of in situ formed β‐Amino Allenes

Abstract We have developed a simple, One‐Pot, three‐component reaction of tert ‐propargyl alcohols, primary amines and acyl ketones to synthesize fully substituted pyrroles and pyridine derivatives in good to excellent yields with large substrate diversity. An eco‐friendly calcium catalyst catalyzes the reaction to form the key intermediate β ‐amino allene that undergoes subsequent Thorpe‐Ingold effect assisted hydroamination and aromaticity driven deacylation reaction to yield fully substituted five and six‐membered azacyclic compounds. magnified image