阿霉素
阳离子聚合
甲基丙烯酸
体内
细胞毒性
化学
分子印迹聚合物
药物输送
溶血
流式细胞术
体外
聚合物
核化学
材料科学
癌症研究
高分子化学
生物化学
分子生物学
选择性
医学
化疗
有机化学
生物
免疫学
内科学
单体
催化作用
生物技术
作者
Nahid Farhad-Gholami,Hamid Hashemi‐Moghaddam,Masoud Shaabanzadeh,Saeed Zavareh,Hamid Madanchi
标识
DOI:10.1080/00914037.2021.2008392
摘要
In this study, Poly(methacrylic acid-co-diallyldimethylammonium chloride) or Poly(MAA-PDDA) was synthesized as a cationic molecularly imprinted nano-polymer. After in vitro assays such as cytotoxicity assay and hemolysis activity test, this imprinted nano-polymer was examined for targeted Doxorubicin (DOX) delivery in BALB/c mice bearing MCF7 human breast carcinoma cells. In vivo studies of synthesized nanoparticles on BALB/c mice showed their selectivity. Also, it was found that tumor growth delay (TGD) improved from 1.11 in DOX treated group to 2.82 in cationic polymer combined with DOX. Imprinted cationic polymer provides remarkable prevention of tumor growth. Investigating drug deposition in various tissues showed that DOX concentration was considerably more in tumors than in other tissues.
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