免疫原性
放化疗
免疫系统
CD8型
宫颈癌
医学
放射治疗
外周血单个核细胞
癌症研究
癌症
免疫学
肿瘤科
病理
作者
Jianzhou Chen,Chuang-Zhen Chen,Yizhou Zhan,Li Zhou,Jie Chen,Qingxin Cai,Yanxuan Wu,Zhihan Sui,Chengbing Zeng,Xiao-Long Wei,Ruth J. Muschel
标识
DOI:10.1158/1078-0432.ccr-20-4521
摘要
Purpose: To ask whether the expression of immune markers and IFN signaling in tumor biopsies changes during concurrent chemoradiotherapy (CCRT). Experimental Design: Tumor biopsies and peripheral mononuclear blood cells (PMBC) before and immediately after 20 Gy/10 fractions (F) of radiation treatment (RT) from 30 patients with cervical cancer receiving CCRT were evaluated by IHC and qRT-PCR for immune markers and correlated with the short-term response. Results: Tumor immune response to radiation before and after 10F RT as reflected by CD8+ T-cell infiltration had substantial heterogeneity with increases, decreases, and no change all evident. Increases in CD8+ T cells during CCRT correlated with the presence of nuclear IRF1 in tumor cells (r = 0.68, P Conclusions: CCRT leads to differential tumor immunogenicity and IFN signaling in patients with cervical cancer, suggesting radiation induction of immunity is limited to a subset of patients and may reflect the heterogeneity of intratumoral induction of IFNs.
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