Animal models of diabetes : methods and protocols

Preface...Table of Contents...Contributing Authors... 1. Practical Considerations when Using Mouse Models of DiabetesAileen J.F. King, Lydia F. Daniels Gatward, and Matilda R. Kennard 2. An Overview of Rodent Models of Obesity and Type 2 DiabetesThomas A. Lutz 3. Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON MiceMototsugu Nagao, Jonathan Lou S. Esguerra, Anna Wendt, Akira Asai, Hitoshi Sugihara, Shinichi Oikawa, and Lena Eliasson 4. A Review of Mouse Models of Monogenic Diabetes and ER Stress SignallingParaskevi Salpea, Cristina Cosentino, and Mariana Igoillo-Esteve 5. Rat Models of Human Type 1 Diabetes Sigurd Lenzen, Tanja Arndt, Matthias Elsner, Dirk Wedekind, and Anne Joerns 6. Mouse Models of Autoimmune Diabetes: The Non-Obese Diabetic (NOD) Mouse Dawei Chen, Terri C. Thayer, Li Wen, and F. Susan Wong 7. Mouse Models of Virus-Induced Type 1 DiabetesGustaf Christoffersson and Malin Flodstroem-Tullberg 8. Rat Models of Virus-Induced Type 1 DiabetesJames C. Needell and Danny Zipris 9. Large Animal Models of DiabetesBarbara Ludwig, Eckhard Wolf, Uwe Schoenmann, and Stefan Ludwig 10. Use of Streptozotocin in Rodent Models of Islet Transplantation Aileen King, Elisabet Estil-les, and Eduard Montanya 11. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging Christian M. Cohrs, Chunguang Chen, and Stephan Speier 12. Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in ZebrafishSumeet Pal Singh and Nikolay Ninoy 13. Generating Beta-Cell Specific Transgenic Mice Using the Cre-Lox SystemLorna I.F. Smith, Thomas G. Hill, and James E. Bowe 14. The Glucose Tolerance Test in MicePatricia Fonseca Pedro, Anastasia Tsakmaki, and Gavin A. Bewick 15. Assessment of Insulin Tolerance In Vivo in MiceIrene Cozar-Castellano and German Perdomo 16. Continuous Glucose Monitoring in Conscious Unrestrained MiceAileen J.F. King, Matilda R. Kennard, and Manasi Nandi 17. Assessing Mouse Islet FunctionPatricio Atanes, Inma Ruz-Maldonado, Oladapo E. Olaniru, and Shanta J. Persaud 18. Assessing Immune Responses in the Nonobese Diabetic Mouse Model of Type 1 DiabetesTerri C. Thayer, Dimitri Kakabadse, Joanne Boldison, and F. Susan Wong 19. Assessment of Insulin Tolerance Ex VivoIrene Cozar-Castellano and German Perdomo 20. Using Pancreas Tissue Slices for the Study of Islet PhysiologyJulia K. Panzer, Christian M. Cohrs, and Stephan Speier 21. Determining Beta Cell Mass, Apoptosis, Proliferation, and Individual Beta Cell Size in Pancreatic SectionsNoelia Tellez and Eduard Montanya Subject Index List...