Subtherapeutic levels of voriconazole in continuous renal replacement therapy patients

Voriconazole is an antifungal widely used in the treatment of invasive fungal infections, thus pharmacokinetic monitoring is highly important to achieve appropriate dosages. It has been described that patients undergoing continuous renal replacement therapy did not see plasma voriconazole concentrations altered. Two cases are presented in which subtherapeutic voriconazole plasma levels are obtained while the patients are in continuous venovenous hemodiafiltration.