活性氧
光热治疗
热休克蛋白
过氧化物酶
脂质过氧化
生物物理学
化学
GPX4
癌症研究
谷胱甘肽
热疗
氧化应激
癌症治疗
材料科学
细胞生物学
纳米技术
生物化学
癌症
谷胱甘肽过氧化物酶
酶
医学
生物
内科学
基因
作者
Mengyu Chang,Zhiyao Hou,Man Wang,Chunzheng Yang,Ruifeng Wang,Fang Li,Donglian Liu,Tieli Peng,Chunxia Li,Jun Lin
标识
DOI:10.1002/anie.202101924
摘要
Abstract Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia is easily repaired by stress‐induced heat shock proteins (HSPs). Thus, maximizing the PTT efficiency and minimizing the damage to healthy tissues simultaneously by adopting appropriate therapeutic temperatures is imperative. Herein, an innovative strategy is reported: ferroptosis‐boosted mild PTT based on a single‐atom nanozyme (SAzyme). The Pd SAzyme with atom‐economical utilization of catalytic centers exhibits peroxidase (POD) and glutathione oxidase (GSHOx) mimicking activities, and photothermal conversion performance, which can result in ferroptosis featuring the up‐regulation of lipid peroxides (LPO) and reactive oxygen species (ROS). The accumulation of LPO and ROS provides a powerful approach for cleaving HSPs, which enables Pd SAzyme‐mediated mild‐temperature PTT.
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