Enantioselective Conjugate Addition of Alkenylboronic Acids to Indole-Appended Enones

An enantioselective addition of alkenylboronic acids and alkynylboronic esters to unprotected indole-appended enones is reported. This transformation proceeds with high enantioselectivity and high product yields via the use of catalytic amounts of 3,3'-bis(pentafluorophenyl)-BINOL and Mg(Ot-Bu)(2). A range of α-branched indole derivatives are available from the transformation.