InCl3-Catalyzed Highly Regioselective Ring Opening of Epoxides with Thiols

Abstract Epoxides react smoothly with thiols in the presence of 10 mol% InCl3 under very mild conditions to afford the corresponding β-hydroxy sulfides in high yields with high regioselectivity. Similar yields and selectivity are also obtained with catalytic amount of indium triflate under these reaction conditions.