医学
心脏毒性
卡培他滨
氟尿嘧啶
血管痉挛性心绞痛
心绞痛
内科学
冠状动脉痉挛
心脏病学
化疗
癌症
结直肠癌
心肌梗塞
作者
Tanya Stewart,Nick Pavlakis,Michael R. Ward
标识
DOI:10.1111/j.1445-5994.2009.02144.x
摘要
In this case series we present a variety of different cardiac toxicities with 5-fluorouracil and its pro-drug capecitabine, including myocardial infarction, cardiomyopathy, sinoatrial and atrioventricular node dysfunction, takotsubo cardiomyopathy and QT prolongation with torsade-de pointes ventricular tachycardia. We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided.
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