Enzymatic Reduction of Benzamidoxime to Benzamidoxine

Abstract Strongly basic amidine functions are components of numerous active principles. Our investigations on the biotransformations of this functional group have provided evidence for the N ‐demethylation of N ‐methylbenzamidine and the N ‐hydroxylation of amidine functions without α‐hydrogen atoms 3, 4) . The pharmacological and toxicological relevance of the N ‐oxygenations of amidine functional groups als been demonstrated.