GTP酶
细胞生物学
肌动蛋白细胞骨架
运动性
细胞骨架
生物
肌动蛋白
细胞迁移
肌动蛋白重塑
细胞
遗传学
作者
Désirée Spiering,Louis Hodgson
标识
DOI:10.4161/cam.5.2.14403
摘要
The p21 Rho-family of small GTPases are master regulators of actin cytoskeleton rearrangements. Their functions have been well characterized in terms of their effects toward various actin-modulating protein targets. However, more recent studies have shown that the dynamics of Rho GTPase activities are highly complex and tightly regulated in order to achieve their specific subcellular localization. Furthermore, these localized effects are highly dynamic, often spanning the time-scale of seconds, making the interpretation of traditional biochemical approaches inadequate to fully decipher these rapid mechanisms in vivo. Here, we provide an overview of Rho family GTPase biology, and introduce state-of-the-art approaches to study the dynamics of these important signaling proteins that ultimately coordinate the actin cytoskeleton rearrangements during cell migration.
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