Preparation of α‐Cyclodextrin‐Terminated Polyrotaxane Consisting of β‐Cyclodextrins and Pluronic as a Building Block of a Biodegradable Network

Abstract Summary: A β ‐CD‐based biodegradable polyrotaxane was prepared by capping both terminals of polypseudorotaxane consisting of hydrazide‐terminated PEG‐ block ‐PPG‐ block ‐PEG (Pluronic P‐105®) and β ‐CD‐succinates with mono‐aldehyde α ‐CDs. By decreasing pH, the fluorescent intensity of TNS was increased with time, indicating cleavage of the terminal hydrazone bonds followed by β ‐CD‐succinate release. The terminal α ‐CD moieties of the polyrotaxane are useful for self‐assembled formation with some guest molecules. magnified image