Dectin-1 limits allergic responses

Allergy Aberrant activation of pattern recognition receptors (PRRs) drives inflammation in autoimmune and allergic diseases. Gour et al. identified invertebrate tropomyosin from house dust mites and shrimp as a ligand for dectin-1. Dectin-1 is a PRR that recognizes fungal β-glucans in antifungal immune responses. Engagement of dectin-1 by invertebrate tropomyosins limited type 2 inflammation, and dectin-1–deficient mice were more prone to allergic airway inflammation. Furthermore, expression of dectin-1 was repressed in allergic individuals. Thus, dectin-1 is important in limiting allergic responses. Sci. Immunol. 3 , eaam9841 (2018).