胚胎学
病因学
序列(生物学)
解剖
生物
个体发育
下颌骨(节肢动物口器)
表型
气道阻塞
病理
医学
遗传学
气道
外科
基因
动物
属
作者
Robrecht J. H. Logjes,Corstiaan C. Breugem,Gijs van Haaften,Emma C. Paes,G.H. Sperber,Marie‐José H. van den Boogaard,Peter Farlie
摘要
The triad of micrognathia, glossoptosis, and concomitant airway obstruction defined as "Robin sequence" (RS) is caused by oropharyngeal developmental events constrained by a reduced stomadeal space. This sequence of abnormal embryonic development also results in an anatomical configuration that might predispose the fetus to a cleft palate. RS is heterogeneous and many different etiologies have been described including syndromic, RS-plus, and isolated forms. For an optimal diagnosis, subsequent treatment and prognosis, a thorough understanding of the embryology and pathogenesis is necessary. This manuscript provides an update about our current understanding of the development of the mandible, tongue, and palate and possible mechanisms involved in the development of RS. Additionally, we provide the reader with an up-to-date summary of the different etiologies of this phenotype and link this to the embryologic, developmental, and genetic mechanisms.
科研通智能强力驱动
Strongly Powered by AbleSci AI