计算生物学
代谢组
生物
系统生物学
代谢工程
药物发现
作者
Katherine A. Hollywood,Kamila Schmidt,Eriko Takano,Rainer Breitling
标识
DOI:10.1016/j.copbio.2018.02.015
摘要
Metabolomics plays an increasingly central role within the Design-Build-Test cycle of synthetic biology, in particular in applications targeting the discovery, diversification and optimised production of a wide range of natural products. For example, improved methods for the online monitoring of chemical reactions accelerate data generation to be compatible with the rapid iterations and increasing library sizes of automated synthetic biology pipelines. Combinations of label-free metabolic profiling and 13C-based flux analysis lead to increased resolution in the identification of metabolic bottlenecks affecting product yield in engineered microbes. And molecular networking strategies drastically increase our ability to identify and characterise novel chemically complex biomolecules of interest in a diverse range of samples.
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