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This issue marks the 125th anniversary of Science, and anniversaries frequently bring our attention back to the last major one. The centennial issue emerged on 4 July 1980,* and I missed it because I was struggling with a professional transition of my own. So in preparation for this celebration, I naturally got hold of a copy as soon as I could. It's an interesting document in a number of ways. In part it looks backward—at the journal and its role in the history of science, and through splendid status reports on each of the broad research disciplines that Science covers. But it also looks ahead. Fred Mosteller, the distinguished statistician who was president of the American Association for the Advancement of Science (AAAS) in that centennial year, entitled his contribution "The Next 100 Years of Science." He used that essay to voice some concerns about science policy and even to make a few predictions.