Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) for solar dermatitis

Solar dermatitis is an acute or chronic high incidence of skin injury caused by ultraviolet (UV) radiation based on strong sunlight, which seriously endangers people’s health. In this study, we designed and demonstrated enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) sprayable nanodrug-loaded hydrogels based on gelatin, 3-(4-hydroxyphenyl) propionic acid (HPA), polyvinyl alcohol (PVA), glycerol, and dexamethasone sodium phosphate (DEXP) for solar dermatitis. The hydrogels had high water content, excellent biocompatibility, effective encapsulation and sustained release of nanodrugs, anti-inflammatory, and strong anti-ultraviolet B (anti-UVB) radiation properties based on glycerol and phenol functional groups, but also controllable spray gelation mode to make them adhere well on the dynamic skin surfaces and achieve continuous transdermal drugs delivery for solar dermatitis. The sprayable nanodrug-loaded hydrogel systems could be used as a highly effective therapeutic method for solar dermatitis, and also provide a good strategy for designing novel nanodrug-loaded hydrogel delivery systems.