大麻酚
牙周组织
内大麻素系统
大麻素受体
免疫系统
医学
大麻
大麻素
炎症
炎症反应
生物
免疫学
受体
精神科
内科学
牙科
兴奋剂
作者
Petr Jirásek,A Jusku,Vilı́m Šimánek,Jana Franková,Jan Storch,Jan Vacek
摘要
Cannabidiol (CBD), a non-psychotropic cannabinoid produced by the genus Cannabis, is a phytoceutical that activates the endocannabinoid system (ECS) through binding to CB1 and CB2 receptors. The ECS is involved in cellular homeostasis and regulates metabolic processes in virtually all mammalian tissues. Published studies on CBD focus, inter alia, on its use in prophylaxis and as an anti-inflammatory agent. Here the authors present a critical assessment of the effects of CBD on inflammatory periodontal diseases caused by bacterial virulence factors, and evaluate critically the possible benefits and drawbacks of CBD use in dentistry. Particular attention is paid to the interaction of CBD with microbially colonized oral tissues, the inflammatory response in relation to the immune response, and the destruction/regeneration of hard and soft tissues of the periodontium.
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