抵抗性
土壤水分
农业
环境科学
基因组
风险分析(工程)
风险评估
多学科方法
环境卫生
环境化学
抗生素
抗生素耐药性
业务
生物
计算机科学
生态学
化学
土壤科学
微生物学
医学
基因
计算机安全
生物化学
社会学
整合子
社会科学
作者
Yuxin Zhang,Jinping Chen,Haiyang Chen,Linmei Liu,Chang Liu,Yanguo Teng
标识
DOI:10.1016/j.jhazmat.2021.128113
摘要
In this study, a new integrated multidisciplinary-based framework has been proposed to better understand the environmental risks of heavy metals (HMs) in agricultural soils. The source apportionment results revealed by a multilinear engine model were incorporated into the geochemical indexes and the probabilistic health risk assessment models for identifying the source-oriented risks of HMs in the environment. High-throughput sequencing-based metagenomic assembly analysis was used for characterizing the prevalence and dissemination risk of antibiotic resistomes and their associations with the geochemical enrichment of HMs in the soils. Results showed agricultural and industrial activities were the main sources of HMs in the environment. Although the soils were contaminated moderately by HMs and the health risks posed by soil metals were negligible for both adult and children, source-oriented risk evaluation suggested agricultural activities contributed relatively higher contamination and health risks than the other sources. Notably, abundant and diverse antibiotic resistant genes, mobile gene elements, virulence factors, and antibiotic-resistant bacterial pathogens were identified in the agricultural soils, as well as their co-occurrences on the same contigs, implying a non-negligible resistome risk. Further, statistical and network analyses showed the geochemical enrichment of HMs exerted significant effects on the antibiotic resistomes in the environment.
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