抗苗勒氏激素
卵胞浆内精子注射
医学
妇科
卵巢储备
辅助生殖技术
生物标志物
男科
不育
前瞻性队列研究
促排卵
激素
内科学
怀孕
排卵
生物
生物化学
遗传学
作者
Rong Li,Fei Gong,Yimin Zhu,Wen‐Hui Fang,Jing Yang,Jiayin Liu,Linli Hu,Dongzi Yang,Xiaoyan Liang,Jie Qiao
标识
DOI:10.1016/j.rbmo.2016.07.003
摘要
This study explored the correlation between serum anti-Müllerian hormone (AMH) concentration and the number of retrieved oocytes after ovarian stimulation in Chinese infertile women undergoing assisted reproductive technology treatment and AMH cut-off values predicting low and high ovarian response. This was a prospective, multi-centre, observational study. A total of 615 subjects were included in nine assisted reproductive centres in China for outcome analysis. Subjects received assisted reproductive technology treatment and used recombinant human FSH (r-HFSH) or r-HFSH plus recombinant LH (rLH) for ovarian stimulation according to conventional treatment regimens. The main outcome variables were correlations between AMH and the number of retrieved oocytes and the cut-off values of AMH predicting low and high ovarian response. Serum AMH concentration was positively correlated with the number of oocytes retrieved in Chinese infertile women treated with IVF/intracytoplasmic sperm injection (ICSI) (Pearson correlation coefficient = 0.4754, P < 0.0001). The optimal AMH cut-off value was 2.6 ng/ml (sensitivity: 81.28%, specificity: 59.51%) in predicting high and normal response, and 1.1 ng/ml (sensitivity: 52.27%, specificity: 87.23%) in predicting low and normal response. In conclusion, serum AMH concentration can be used as a biomarker to predict ovarian response in Chinese infertile women treated with assisted reproductive technology.
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