材料科学
骨整合
钛
成骨细胞
纳米颗粒
细胞毒性
纳米材料
壳聚糖
纳米技术
人口
银纳米粒子
生物物理学
植入
化学
生物化学
体外
人口学
社会学
外科
冶金
生物
医学
作者
Huiliang Cao,Wenjie Zhang,Fanbin Meng,Jinshu Guo,Donghui Wang,Qian Shi,Xinquan Jiang,Xuanyong Liu,Paul K. Chu
标识
DOI:10.1021/acsami.6b15448
摘要
Silver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin α5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium. It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin α5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs. Since cellular uptake is a key factor determining the cytotoxic performance of Ag NPs, the extracellular effects of immobilized Ag NPs on promoting osteogenesis provided new insights into the safe application of nanomaterials, and into designing and developing renewed antibacterial devices with selective toxicity.
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