亚甲蓝
吩噻嗪
黑色素瘤
细胞毒性
黑色素
化学
细胞培养
光敏剂
亚甲基
光动力疗法
细胞
癌症研究
体外
药理学
光化学
生物化学
医学
生物
有机化学
催化作用
光催化
遗传学
作者
Lesley Rice,Mark Wainwright,David A. Phoenix
出处
期刊:PubMed
日期:2000-02-01
卷期号:12 (1): 94-104
被引量:12
标识
DOI:10.1179/joc.2000.12.1.94
摘要
The cytotoxicity and photocytotoxicity of methylene blue and several of its derivatives against two pigmented melanoma cell lines (SK-23 murine melanoma and SK-Mel 28 human melanoma) were investigated in culture. The derivatives were all more effective photosensitizers than methylene blue in both cell lines over a range of light doses (3.6-17.6 J cm(-2)). The increased activity correlated with increased cellular uptake and inherent photosensitizing efficacy. The photosensitizers also showed varying levels of interaction with the biopolymer melanin and although this appeared to affect uptake and activity, there was no direct correlation with toxicity.
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