机械转化
生物物理学
纳米尺度
执行机构
整合素
粘附
纳米技术
受体
运动性
细胞
材料科学
化学
生物
细胞生物学
工程类
电气工程
有机化学
生物化学
作者
Zheng Liu,Yang Liu,Yu-Jen Chang,Hamid Reza Seyf,Asegun Henry,Alexa L. Mattheyses,Kevin Yehl,Yun Zhang,Zhuangqun Huang,Khalid Salaita
出处
期刊:Nature Methods
[Springer Nature]
日期:2015-12-14
卷期号:13 (2): 143-146
被引量:112
摘要
To control receptor tension optically at the cell surface, we developed an approach involving optomechanical actuator nanoparticles that are controlled with near-infrared light. Illumination leads to particle collapse, delivering piconewton forces to specific cell surface receptors with high spatial and temporal resolution. We demonstrate optomechanical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation.
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