蛋白质精氨酸甲基转移酶5
生物
组蛋白
甲基转移酶
癌症
甲基化
精氨酸
计算生物学
癌症研究
生物化学
遗传学
基因
氨基酸
作者
Wenke Jin,Jin Zhang,Xiya Chen,Yin Su,Haibin Yu,Feng Gao,Dahong Yao
标识
DOI:10.1016/j.bbcan.2023.188916
摘要
Coactivator-associated arginine methyltransferase 1 (CARM1), a type I protein arginine methyltransferase (PRMT), has been widely reported to catalyze arginine methylation of histone and non-histone substrates, which is closely associated with the occurrence and progression of cancer. Recently, accumulating studies have demonstrated the oncogenic role of CARM1 in many types of human cancers. More importantly, CARM1 has been emerging as an attractive therapeutic target for discovery of new candidate anti-tumor drugs. Therefore, in this review, we summarize the molecular structure of CARM1 and its key regulatory pathways, as well as further discuss the rapid progress in better understanding of the oncogenic functions of CARM1. Moreover, we further demonstrate several representative targeted CARM1 inhibitors, especially focusing on demonstrating their designing strategies and potential therapeutic applications. Together, these inspiring findings would shed new light on elucidating the underlying mechanisms of CARM1 and provide a clue on discovery of more potent and selective CARM1 inhibitors for the future targeted cancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI