A Tricyclo[4.3.1]decane Diterpenoid Skeleton from Croton laui: Isolation and 1H NMR-Based Metabolomic Profiling

Lauicyclone A (1), a new skeletal diterpenoid characterized by an unprecedented carbon skeleton, represents the first reported natural product featuring a complex tricyclo[4.3.1]decane framework. Along with Lauicyclones B-E (2-5), all five compounds were isolated from Croton laui. Comprehensive spectroscopic analyses, quantum-chemical calculations, and X-ray diffractions were used to identify their structures. The antitumor mechanism of compound 1 was investigated using 1H NMR-based metabolomics.